Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats

BACKGROUND: Botulinum neurotoxin type A, an FDA-approved prophylactic drug for chronic migraine, is thought to achieve its therapeutic effect through blocking activation of unmyelinated meningeal nociceptors and their downstream communications with myelinated nociceptors and potentially the vasculat...

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Publicat a:Cephalalgia
Autors principals: Melo-Carrillo, Agustin, Strassman, Andrew M, Schain, Aaron J, Noseda, Rodrigo, Ashina, Sait, Adams, Aubrey, Brin, Mitchell F, Burstein, Rami
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2019
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779016/
https://ncbi.nlm.nih.gov/pubmed/31475573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0333102419873675
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