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An Antibody to Notch3 Reverses the Skeletal Phenotype of Lateral Meningocele Syndrome in Male Mice
Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse model of LMS (Notch3(tm1.1Ecan)) by introducing a tandem termination codon in the Notch3 locus upstream of the PEST domain. Microco...
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| Vydáno v: | J Cell Physiol |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6778702/ https://ncbi.nlm.nih.gov/pubmed/31188489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.28960 |
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