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An Antibody to Notch3 Reverses the Skeletal Phenotype of Lateral Meningocele Syndrome in Male Mice

Lateral meningocele syndrome (LMS), a genetic disorder characterized by meningoceles and skeletal abnormalities, is associated with NOTCH3 mutations. We created a mouse model of LMS (Notch3(tm1.1Ecan)) by introducing a tandem termination codon in the Notch3 locus upstream of the PEST domain. Microco...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Yu, Jungeun, Siebel, Christian W., Schilling, Lauren, Canalis, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778702/
https://ncbi.nlm.nih.gov/pubmed/31188489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.28960
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