Indoleamine 2,3‐dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma

Tryptophan metabolism is important to induce immune tolerance in tumors. To date, 3 types of tryptophan‐metabolizing enzymes have been identified: indoleamine 2,3‐dioxygenase 1 and 2 (IDO1 and IDO2) and tryptophan 2,3‐dioxygenase 2. Numerous studies have focused on IDO1 as its expression is enhanced...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Yamasuge, Wakana, Yamamoto, Yasuko, Fujigaki, Hidetsugu, Hoshi, Masato, Nakamoto, Kentaro, Kunisawa, Kazuo, Mouri, Akihiro, Nabeshima, Toshitaka, Saito, Kuniaki
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778659/
https://ncbi.nlm.nih.gov/pubmed/31444833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14179
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