Impact of Tenofovir-Based Pre-exposure Prophylaxis on Biomarkers of Bone Formation, Bone Resorption, and Bone Mineral Metabolism in HIV-Negative Adults

BACKGROUND: Pre-exposure prophylaxis (PrEP) with emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) reduces the risk of HIV seroconversion but may promote bone mineral density (BMD) decline. The mechanisms of BMD decline with FTC/TDF remain unclear, and studies in HIV-positive individuals have...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Nickolas, Thomas L, Yin, Michael T, Hong, Ting, Mugwanya, Kenneth K, Branch, Andrea D, Heffron, Renee, Ramalho, Janaina, Nandakumar, Renu, Dworakowski, Elzbieta, Wanga, Valentine, Mugo, Nelly R, Ronald, Allan, Celum, Connie, Donnell, Deborah, Baeten, Jared M, Wyatt, Christina M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Major Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778426/
https://ncbi.nlm.nih.gov/pubmed/31660332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz338
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