αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion

Tumors utilize a number of effective strategies, including the programmed death 1/PD ligand 1 (PD-1/PD-L1) axis, to evade immune-mediated control of their growth. PD-L1 expression is mainly induced by IFN receptor signaling or constitutively induced. Integrins are an abundantly expressed class of pr...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Vannini, Andrea, Leoni, Valerio, Barboni, Catia, Sanapo, Mara, Zaghini, Anna, Malatesta, Paolo, Campadelli-Fiume, Gabriella, Gianni, Tatiana
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778255/
https://ncbi.nlm.nih.gov/pubmed/31527243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901931116
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