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Type I Interferon and NF-κB Activation Elicited by Herpes Simplex Virus gH/gL via αvβ3 Integrin in Epithelial and Neuronal Cell Lines

αvβ3 integrin represents a novel sensing system which detects herpes simplex virus (HSV) and bacterial constituents. In cooperation with Toll-like receptor 2 (TLR2), it elicits an innate response that leads to activation of type I interferon (IFN), NF-κB, and a specific set of cytokines. We report t...

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Detalles Bibliográficos
Main Authors: Gianni, Tatiana, Leoni, Valerio, Campadelli-Fiume, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838217/
https://ncbi.nlm.nih.gov/pubmed/24109241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01894-13
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