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Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB

A number of sentinels sense incoming herpes simplex virus (HSV) virions and initiate an immediate innate response. The first line of defense at the cell surface is TLR2 (Toll-like receptor 2), whose signature signaling activity leads to activation of the key transcription factor NF-κB. We report tha...

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Bibliografski detalji
Glavni autori: Leoni, Valerio, Gianni, Tatiana, Salvioli, Stefano, Campadelli-Fiume, Gabriella
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393584/
https://ncbi.nlm.nih.gov/pubmed/22496225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00295-12
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