In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse

Duchenne muscular dystrophy (DMD) is a fatal genetic disorder caused by mutations in the dystrophin gene. To enable the non-invasive analysis of DMD gene correction strategies in vivo, we introduced a luciferase reporter in-frame with the C-terminus of the dystrophin gene in mice. Expression of this...

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Publicat a:Nat Commun
Autors principals: Amoasii, Leonela, Li, Hui, Zhang, Yu, Min, Yi-Li, Sanchez-Ortiz, Efrain, Shelton, John M., Long, Chengzu, Mireault, Alex A., Bhattacharyya, Samadrita, McAnally, John R., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778191/
https://ncbi.nlm.nih.gov/pubmed/31586095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12335-x
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