Association between genetic polymorphisms of NRF2, KEAP1, MAFF, MAFK and anti-tuberculosis drug-induced liver injury: a nested case-control study

Reactive metabolites of anti-tuberculosis (anti-TB) drugs can result in excessive reactive oxygen species (ROS), which are responsible for drug-induced liver injury. The nuclear factor erythroid 2-related factor 2 (Nrf2) - antioxidant response elements (ARE) (Nrf2-ARE) signaling pathway plays a cruc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Shixian, Pan, Hongqiu, Chen, Yongzhong, Lu, Lihuan, He, Xiaomin, Chen, Hongbo, Chen, Ru, Zhan, Siyan, Tang, Shaowen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778130/
https://ncbi.nlm.nih.gov/pubmed/31586142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50706-y
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