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Early skeletal muscle pathology and disease progress in the dy(3K)/dy(3K) mouse model of congenital muscular dystrophy with laminin α2 chain-deficiency

Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently, there is no treatment for this detrimental disorder. Development of therapies is largely hindered by lack of understanding of me...

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Publicat a:Sci Rep
Autors principals: Gawlik, Kinga I., Körner, Zandra, Oliveira, Bruno M., Durbeej, Madeleine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778073/
https://ncbi.nlm.nih.gov/pubmed/31586140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50550-0
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