7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors.

Selective inhibitors of Cryptosporidium Calcium-Dependent Protein Kinase 1 (CpCDPK1) based on the 1H-pyrazolo[3,4-d]pyrimidin-4-amine (pyrazolopyrimidine, PP) scaffold are effective in both in vitro and in vivo models of cryptosporidiosis. However, the search for distinct safety and pharmacokinetic...

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Enregistré dans:
Détails bibliographiques
Publié dans:ACS Infect Dis
Auteurs principaux: Vidadala, Rama S. R., Golkowski, Martin, Hulverson, Matthew A., Choi, Ryan, McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Arnold, Samuel L. M., Barrett, Lynn K., Fan, Erkang, Merritt, Ethan A., Van Voorhis, Wesley C., Ojo, Kayode K., Maly, Dustin J.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777988/
https://ncbi.nlm.nih.gov/pubmed/29522315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00224
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