7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors.

Selective inhibitors of Cryptosporidium Calcium-Dependent Protein Kinase 1 (CpCDPK1) based on the 1H-pyrazolo[3,4-d]pyrimidin-4-amine (pyrazolopyrimidine, PP) scaffold are effective in both in vitro and in vivo models of cryptosporidiosis. However, the search for distinct safety and pharmacokinetic...

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Bibliografski detalji
Izdano u:ACS Infect Dis
Glavni autori: Vidadala, Rama S. R., Golkowski, Martin, Hulverson, Matthew A., Choi, Ryan, McCloskey, Molly C., Whitman, Grant R., Huang, Wenlin, Arnold, Samuel L. M., Barrett, Lynn K., Fan, Erkang, Merritt, Ethan A., Van Voorhis, Wesley C., Ojo, Kayode K., Maly, Dustin J.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777988/
https://ncbi.nlm.nih.gov/pubmed/29522315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00224
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