Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer

IMPORTANCE: Radiation therapy for breast cancer is associated with increased risk of a second primary contralateral breast cancer, but the genetic factors modifying this association are not well understood. OBJECTIVE: To determine whether a genetic risk score comprising single nucleotide polymorphis...

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Vydáno v:JAMA Netw Open
Hlavní autoři: Watt, Gordon P., Reiner, Anne S., Smith, Susan A., Stram, Daniel O., Capanu, Marinela, Malone, Kathleen E., Lynch, Charles F., John, Esther M., Knight, Julia A., Mellemkjær, Lene, Bernstein, Leslie, Brooks, Jennifer D., Woods, Meghan, Liang, Xiaolin, Haile, Robert W., Riaz, Nadeem, Conti, David V., Robson, Mark, Duggan, David, Boice, John D., Shore, Roy E., Tischkowitz, Marc, Orlow, Irene, Thomas, Duncan C., Concannon, Patrick, Bernstein, Jonine L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2019
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777239/
https://ncbi.nlm.nih.gov/pubmed/31560388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.12259
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