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Discovery of Ligand-Efficient Scaffolds for the Design of Novel Trichomonas vaginalis Uridine Nucleoside Ribohydrolase Inhibitors Using Fragment Screening
[Image: see text] Trichomoniasis is caused by the parasitic protozoan Trichomonas vaginalis. The increasing prevalence of strains resistant to the current 5-nitroimidazole treatments creates the need for novel therapies. T. vaginalis cannot synthesize purine and pyrimidine rings and requires salvage...
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| Veröffentlicht in: | ACS Omega |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2019
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6777076/ https://ncbi.nlm.nih.gov/pubmed/31592163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02472 |
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