Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine

Perioperative ischemic stroke usually leads to neurological dysfunction caused by neuron death. During the ischemic condition, excitotoxity due to extracellular glutamate accumulation is a main mechanism of neuron damage. The clearance of glutamate mainly depends on glutamate transporter-1 (GLT-1) w...

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Dettagli Bibliografici
Pubblicato in:Front Neurol
Autori principali: Peng, Mengyuan, Ling, Xiaomin, Song, Ruixue, Gao, Xuan, Liang, Zhifeng, Fang, Fang, Cang, Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Neurology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776610/
https://ncbi.nlm.nih.gov/pubmed/31611842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2019.01041
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