Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by acute intestinal injury. Intestinal stem cell (ISC) renewal is required for gut regeneration in response to acute injury. The Wnt/β-catenin pathway is essential for intestinal renewal and ISC maintenance. We found tha...

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Pubblicato in:Cell Death Dis
Autori principali: Li, Bo, Lee, Carol, Cadete, Marissa, Zhu, Haitao, Koike, Yuhki, Hock, Alison, Wu, Richard Y., Botts, Steven R., Minich, Adam, Alganabi, Mashriq, Chi, Lijun, Zani-Ruttenstock, Elke, Miyake, Hiromu, Chen, Yong, Mutanen, Annika, Ngan, Bo, Johnson-Henry, Kathene C., De Coppi, Paolo, Eaton, Simon, Määttänen, Pekka, Delgado-Olguin, Paul, Sherman, Philip M., Zani, Augusto, Pierro, Agostino
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776513/
https://ncbi.nlm.nih.gov/pubmed/31582728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1987-1
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