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Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis
Major risk factors for necrotizing enterocolitis (NEC) are formula feeding and prematurity; however, their pathogenic mechanisms are unknown. Here, we found that insufficient arginine/nitric oxide synthesis limits blood flow in the intestinal microvasculature, leading to hypoxia, mucosal damage and...
Gardado en:
| Publicado en: | Dis Model Mech |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6918740/ https://ncbi.nlm.nih.gov/pubmed/31704804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040998 |
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