Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease

BACKGROUND: The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting inflammatory responses in inflammatory bowel dise...

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Udgivet i:PLoS One
Main Authors: Deuring, J. Jasper, Li, Meng, Cao, Wanlu, Chen, Sunrui, Wang, Wenshi, de Haar, Colin, van der Woude, C. Janneke, Peppelenbosch, Maikel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776398/
https://ncbi.nlm.nih.gov/pubmed/31581194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221924
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