Analysis of SHIP1 expression and activity in Crohn’s disease patients

BACKGROUND: SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn’s disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Somasundaram, Rajesh, Fernandes, Sandra, Deuring, Jasper J., de Haar, Colin, Kuipers, Ernst J., Vogelaar, Lauran, Middleton, Frank A., van der Woude, C. Janneke, Peppelenbosch, Maikel P., Kerr, William G., Fuhler, Gwenny M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540589/
https://ncbi.nlm.nih.gov/pubmed/28767696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182308
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