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Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells
Mitochondrial metabolism plays a central role in insulin secretion in pancreatic beta-cells. Generation of protonmotive force and ATP synthesis from glucose-originated pyruvate are critical steps in the canonical pathway of glucose-stimulated insulin secretion. Mitochondrial metabolism is intertwine...
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| Pubblicato in: | Biochim Biophys Acta Bioenerg |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6776241/ https://ncbi.nlm.nih.gov/pubmed/29886047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2018.06.006 |
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