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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.
In the pancreatic beta-cell, insulin secretion is stimulated by glucose metabolism resulting in membrane potential-dependent elevation of cytosolic Ca2+ ([Ca2+]c). This cascade involves the mitochondrial membrane potential (delta psi[m]) hyperpolarization and elevation of mitochondrial Ca2+ ([Ca2+]m...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1997
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170007/ https://ncbi.nlm.nih.gov/pubmed/9233793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.13.3833 |
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