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Increase of secondary mutations may be a drug-resistance mechanism for lung adenocarcinoma after radiation therapy combined with tyrosine kinase inhibitor

Objective: To investigate changes in the secondary mutations of tumor in a drug-resistance mechanism for lung adenocarcinoma after radiation therapy combined with tyrosine kinase inhibitor (TKI). Methods: Lung adenocarcinoma cell line PC9 in vitro and xenograft model in nude mice were used to observ...

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Bibliografiske detaljer
Udgivet i:J Cancer
Main Authors: Zhuang, Hongqing, Shi, Siyu, Guo, Yihang, Wang, Zhongqiu
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775686/
https://ncbi.nlm.nih.gov/pubmed/31632481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.35247
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