A fluorescent, [(18)F]-positron-emitting agent for imaging PMSA allows genetic reporting in adoptively-transferred, genetically-modified cells

Clinical trials that involve genome-edited-cells are growing in popularity, where CAR-T immunotherapy and CRISPR editing are more recognized strategies. Genetic reporters are needed to localize the molecular events that these cells cause in patients. Specifically, a non-immunogenic genetic reporter...

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Pubblicato in:ACS Chem Biol
Autori principali: Guo, Hua, Kommidi, Harikrishna, Vedvyas, Yogindra, McCloskey, Jaclyn E., Zhang, Weiqi, Chen, Nandi, Nurili, Fuad, Wu, Amy P., Sayman, Haluk B., Akin, Oguz, Rodriguez, Erik A., Aras, Omer, Jin, Moonsoo M., Ting, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775626/
https://ncbi.nlm.nih.gov/pubmed/31120734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00160
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