Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury

Recently, the role of CXCR2 in nociception has been noted. Our studies provide new evidence that the intrathecal administration of its CINC ligands (Cytokine-Induced Neutrophil Chemoattractant; CXCL1-3) induces pain-like behavior in naïve mice, and the effect occurring shortly after administration i...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Piotrowska, Anna, Rojewska, Ewelina, Pawlik, Katarzyna, Kreiner, Grzegorz, Ciechanowska, Agata, Makuch, Wioletta, Nalepa, Irena, Mika, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775284/
https://ncbi.nlm.nih.gov/pubmed/31616413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02198
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