Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

Extracellular host-derived DNA, as one of damage associated molecular patterns (DAMPs), is associated with allergic type 2 immune responses. Immune recognition of such DNA generates the second messenger cyclic GMP-AMP (cGAMP) and induces type-2 immune responses; however, its role in allergic disease...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Ozasa, Koji, Temizoz, Burcu, Kusakabe, Takato, Kobari, Shingo, Momota, Masatoshi, Coban, Cevayir, Ito, Shuichi, Kobiyama, Kouji, Kuroda, Etsushi, Ishii, Ken J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775192/
https://ncbi.nlm.nih.gov/pubmed/31616416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02212
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