Targeting CDC7 sensitizes resistance melanoma cells to BRAF(V600E)-specific inhibitor by blocking the CDC7/MCM2-7 pathway

Although the utilization of selective BRAF(V600E) inhibitors is associated with improved overall survival in patients with metastatic melanoma, a growing challenge of drug resistance has  emerged. CDC7 has been shown to be overexpressed and associated with poor prognosis in various cancers including...

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Vydáno v:Sci Rep
Hlavní autoři: Gad, Shaimaa A., Ali, Hamdy E. A., Gaballa, Rofaida, Abdelsalam, Rania M., Zerfaoui, Mourad, Ali, Hamed I., Salama, Salwa H., Kenawy, Sanaa A., Kandil, Emad, Abd Elmageed, Zakaria Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6775054/
https://ncbi.nlm.nih.gov/pubmed/31578454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50732-w
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