Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE

BACKGROUND. The Psychiatric Genomics Consortium (PGC) has made major advances in the molecular etiology of MDD, confirming that MDD is highly polygenic. Pathway enrichment results from PGC meta-analyses can also be used to help inform molecular drug targets. Prior to any knowledge of molecular bioma...

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Udgivet i:Psychol Med
Main Authors: Docherty, Anna R., Moscati, Arden, Bigdeli, Tim B., Edwards, Alexis C., Peterson, Roseann E., Adkins, Daniel E., Anderson, John S., Flint, Jonathan, Kendler, Kenneth S., Bacanu, Silviu-Alin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774907/
https://ncbi.nlm.nih.gov/pubmed/30935430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033291719000618
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