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Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE

BACKGROUND. The Psychiatric Genomics Consortium (PGC) has made major advances in the molecular etiology of MDD, confirming that MDD is highly polygenic. Pathway enrichment results from PGC meta-analyses can also be used to help inform molecular drug targets. Prior to any knowledge of molecular bioma...

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Foilsithe in:Psychol Med
Main Authors: Docherty, Anna R., Moscati, Arden, Bigdeli, Tim B., Edwards, Alexis C., Peterson, Roseann E., Adkins, Daniel E., Anderson, John S., Flint, Jonathan, Kendler, Kenneth S., Bacanu, Silviu-Alin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774907/
https://ncbi.nlm.nih.gov/pubmed/30935430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033291719000618
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