Conformational changes in HIV-1 reverse transcriptase that facilitate its maturation

HIV-1 reverse transcriptase (RT) is translated as part of the Gag-Pol polyprotein that is proteolytically processed by HIV-1 protease (PR) to finally become a mature heterodimer, composed of a p66 and a p66-derived 51 kDa subunit, p51. Our prior work suggested that tRNA(Lys3) binding to p66/p66 intr...

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Pubblicato in:Structure
Autori principali: Slack, Ryan L., Ilina, Tatiana V., Xi, Zhaoyong, Giacobbi, Nicholas S., Kawai, Gota, Parniak, Michael A., Sarafianos, Stefan G., Sluis-Cremer, Nicolas, Ishima, Rieko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774901/
https://ncbi.nlm.nih.gov/pubmed/31471129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.08.004
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