LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

FACT (facilitates chromatin transcription) is a protein complex that allows RNA polymerase II (RNAPII) to overcome the nucleosome-induced barrier to transcription. While abundant in undifferentiated cells and many cancers, FACT is not abundant or is absent in most tissues. Therefore, we screened for...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: LeRoy, Gary, Oksuz, Ozgur, Descostes, Nicolas, Aoi, Yuki, Ganai, Rais A., Kara, Havva Ortabozkoyun, Yu, Jia-Ray, Lee, Chul-Hwan, Stafford, James, Shilatifard, Ali, Reinberg, Danny
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774727/
https://ncbi.nlm.nih.gov/pubmed/31616795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay3068
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