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The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening

N-methyl-D-aspartate (NMDA) receptors are transmembrane glutamate-binding ion channels that mediate neurotransmission in mammals. NMDA receptor subunits are tetrameric complexes of GluN1 and GluN2A-D subunits, encoded by the GRIN gene family. Of these subunits, GluN2B is suggested to be required for...

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Bibliografische gegevens
Gepubliceerd in:Proteins
Hoofdauteurs: Wells, Gordon, Yuan, Hongjie, McDaniel, Miranda J., Kusumoto, Hirofumi, Snyder, James P., Liotta, Dennis C, Traynelis, Stephen F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774441/
https://ncbi.nlm.nih.gov/pubmed/30168177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25595
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