Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson’s disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment.

α-Synuclein (αSyn) is central to the neuropathology of Parkinson’s disease (PD) due to its propensity for misfolding and aggregation into neurotoxic oligomers. Nitration/oxidation of αSyn leads to dityrosine crosslinking and aggregation. Myeloperoxidase (MPO) is an oxidant-generating enzyme implicat...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Maki, Richard A, Holzer, Michael, Motamedchaboki, Khatereh, Malle, Ernst, Masliah, Eliezer, Marsche, Gunther, Reynolds, Wanda F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774439/
https://ncbi.nlm.nih.gov/pubmed/31175983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.05.033
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