Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression

Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bonifacino, Tiziana, Rebosio, Claudia, Provenzano, Francesca, Torazza, Carola, Balbi, Matilde, Milanese, Marco, Raiteri, Luca, Usai, Cesare, Fedele, Ernesto, Bonanno, Giambattista
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774337/
https://ncbi.nlm.nih.gov/pubmed/31540330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184552
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