Genome-wide cell-free DNA fragmentation in patients with cancer

Cell-free DNA (cfDNA) in the blood provides a noninvasive diagnostic avenue for patients with cancer(1). However, characteristics of the origins and molecular features of cfDNA are poorly understood. We developed an approach to evaluate fragmentation patterns of cfDNA across the genome and found tha...

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Опубликовано в: :Nature
Главные авторы: Cristiano, Stephen, Leal, Alessandro, Phallen, Jillian, Fiksel, Jacob, Adleff, Vilmos, Bruhm, Daniel C., Jensen, Sarah Østrup, Medina, Jamie E., Hruban, Carolyn, White, James R., Palsgrove, Doreen N., Niknafs, Noushin, Anagnostou, Valsamo, Forde, Patrick, Naidoo, Jarushka, Marrone, Kristen, Brahmer, Julie, Woodward, Brian D., Husain, Hatim, van Rooijen, Karlijn L., Ørntoft, Mai-Britt Worm, Madsen, Anders Husted, van de Velde, Cornelis J.H., Verheij, Marcel, Cats, Annemieke, Punt, Cornelis J.A., Vink, Geraldine R., van Grieken, Nicole C.T., Koopman, Miriam, Fijneman, Remond J.A., Johansen, Julia S., Nielsen, Hans Jørgen, Meijer, Gerrit A., Andersen, Claus Lindbjerg, Scharpf, Robert B., Velculescu, Victor E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774252/
https://ncbi.nlm.nih.gov/pubmed/31142840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1272-6
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