Genome-wide cell-free DNA fragmentation in patients with cancer

Cell-free DNA (cfDNA) in the blood provides a noninvasive diagnostic avenue for patients with cancer(1). However, characteristics of the origins and molecular features of cfDNA are poorly understood. We developed an approach to evaluate fragmentation patterns of cfDNA across the genome and found tha...

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Publicado en:Nature
Autores principales: Cristiano, Stephen, Leal, Alessandro, Phallen, Jillian, Fiksel, Jacob, Adleff, Vilmos, Bruhm, Daniel C., Jensen, Sarah Østrup, Medina, Jamie E., Hruban, Carolyn, White, James R., Palsgrove, Doreen N., Niknafs, Noushin, Anagnostou, Valsamo, Forde, Patrick, Naidoo, Jarushka, Marrone, Kristen, Brahmer, Julie, Woodward, Brian D., Husain, Hatim, van Rooijen, Karlijn L., Ørntoft, Mai-Britt Worm, Madsen, Anders Husted, van de Velde, Cornelis J.H., Verheij, Marcel, Cats, Annemieke, Punt, Cornelis J.A., Vink, Geraldine R., van Grieken, Nicole C.T., Koopman, Miriam, Fijneman, Remond J.A., Johansen, Julia S., Nielsen, Hans Jørgen, Meijer, Gerrit A., Andersen, Claus Lindbjerg, Scharpf, Robert B., Velculescu, Victor E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774252/
https://ncbi.nlm.nih.gov/pubmed/31142840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1272-6
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