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Effects of Halothane on GABA(A) Receptor Kinetics: Evidence for Slowed Agonist Unbinding

Many anesthetics, including the volatile agent halothane, prolong the decay of GABA(A) receptor-mediated IPSCs at central synapses. This effect is thought to be a major factor in the production of anesthesia. A variety of different kinetic mechanisms have been proposed for several intravenous agents...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Li, Xiaoshen, Pearce, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774186/
https://ncbi.nlm.nih.gov/pubmed/10648694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-03-00899.2000
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