Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons

The ubiquitin–proteasome protein degradation pathway is crucial in controlling intracellular levels of a variety of short-lived proteins and maintaining cellular growth and metabolism. In a previous study, we showed the accumulation of conjugated ubiquitin in CA1 neurons of the gerbil after 5 min of...

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Vydáno v:J Neurosci
Hlavní autoři: Qiu, Jian Hua, Asai, Akio, Chi, Shunji, Saito, Nobuhito, Hamada, Hirofumi, Kirino, Takaaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774120/
https://ncbi.nlm.nih.gov/pubmed/10627603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-01-00259.2000
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