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Topoisomerases and cancer chemotherapy: recent advances and unanswered questions

DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription, recombination, and chromosome segregation. Stud...

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Detalhes bibliográficos
Publicado no:F1000Res
Main Authors: Bjornsti, Mary-Ann, Kaufmann, Scott H.
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Limited 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774054/
https://ncbi.nlm.nih.gov/pubmed/31602296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.20201.1
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