NUMT Confounding Biases Mitochondrial Heteroplasmy Calls in Favor of the Reference Allele

Homology between mitochondrial DNA (mtDNA) and nuclear DNA of mitochondrial origin (nuMTs) causes confounding when aligning short sequence reads to the reference human genome, as the true sequence origin cannot be determined. Using a systematic in silico approach, we here report the impact of all po...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Maude, Hannah, Davidson, Mira, Charitakis, Natalie, Diaz, Leo, Bowers, William H. T., Gradovich, Eva, Andrew, Toby, Huntley, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773831/
https://ncbi.nlm.nih.gov/pubmed/31612134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00201
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