CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression

CD98 heavy chain (CD98hc) forms heteromeric amino acid (AA) transporters by interacting with different light chains. Cancer cells overexpress CD98hc-transporters in order to meet their increased nutritional and antioxidant demands, since they provide branched-chain AA (BCAA) and aromatic AA (AAA) av...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cano-Crespo, Sara, Chillarón, Josep, Junza, Alexandra, Fernández-Miranda, Gonzalo, García, Judit, Polte, Christine, R. de la Ballina, Laura, Ignatova, Zoya, Yanes, Óscar, Zorzano, Antonio, Stephan-Otto Attolini, Camille, Palacín, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773781/
https://ncbi.nlm.nih.gov/pubmed/31575908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50547-9
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