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The translational machinery of human CD4(+) T cells is poised for activation and controls the switch from quiescence to metabolic remodelling

Naïve T cells respond to TcR activation by leaving quiescence, remodelling metabolism, initiating expansion and differentiating toward effector cells. The molecular mechanisms coordinating the transition from naive to effector is central to the functioning of the immune system, but still elusive. He...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Ricciardi, Sara, Manfrini, Nicola, Alfieri, Roberta, Calamita, Piera, Crosti, Maria Cristina, Simone, Gallo, Müller, Rolf, Pagani, Massimiliano, Abrignani, Sergio, Biffo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773601/
https://ncbi.nlm.nih.gov/pubmed/30197303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.08.009
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