Hemozoin produced by mammals confers heme tolerance

Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter SLC48A1 (also known as...

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Vydáno v:eLife
Hlavní autoři: Pek, Rini H, Yuan, Xiaojing, Rietzschel, Nicole, Zhang, Jianbing, Jackson, Laurie, Nishibori, Eiji, Ribeiro, Ana, Simmons, William, Jagadeesh, Jaya, Sugimoto, Hiroshi, Alam, Md Zahidul, Garrett, Lisa, Haldar, Malay, Ralle, Martina, Phillips, John D, Bodine, David M, Hamza, Iqbal
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773446/
https://ncbi.nlm.nih.gov/pubmed/31571584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49503
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