Hemozoin produced by mammals confers heme tolerance

Free heme is cytotoxic as exemplified by hemolytic diseases and genetic deficiencies in heme recycling and detoxifying pathways. Thus, intracellular accumulation of heme has not been observed in mammalian cells to date. Here we show that mice deficient for the heme transporter SLC48A1 (also known as...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Pek, Rini H, Yuan, Xiaojing, Rietzschel, Nicole, Zhang, Jianbing, Jackson, Laurie, Nishibori, Eiji, Ribeiro, Ana, Simmons, William, Jagadeesh, Jaya, Sugimoto, Hiroshi, Alam, Md Zahidul, Garrett, Lisa, Haldar, Malay, Ralle, Martina, Phillips, John D, Bodine, David M, Hamza, Iqbal
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2019
Sujets:
Biochemistry and Chemical Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773446/
https://ncbi.nlm.nih.gov/pubmed/31571584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49503
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