Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancers

PURPOSE: BRCA1/2-mutated and some sporadic triple-negative breast cancers (TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics. Recently, three independent DNA-based measures of genomic instability were developed on the basis of loss of heterozygosity (LOH), telomeric alleli...

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Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Telli, Melinda L., Timms, Kirsten M., Reid, Julia, Hennessy, Bryan, Mills, Gordon B., Jensen, Kristin C., Szallasi, Zoltan, Barry, William T., Winer, Eric P., Tung, Nadine M., Isakoff, Steven J., Ryan, Paula D., Greene-Colozzi, April, Gutin, Alexander, Sangale, Zaina, Iliev, Diana, Neff, Chris, Abkevich, Victor, Jones, Joshua T., Lanchbury, Jerry S., Hartman, Anne-Renee, Garber, Judy E., Ford, James M., Silver, Daniel P., Richardson, Andrea L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773427/
https://ncbi.nlm.nih.gov/pubmed/26957554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2477
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