Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes

INTRODUCTION: Homologous recombination (HR) DNA repair is of clinical relevance in breast cancer. Three DNA-based homologous recombination deficiency (HRD) scores (HRD-loss of heterozygosity score (LOH), HRD-telomeric allelic imbalance score (TAI), and HRD-large-scale state transition score (LST)) h...

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Bibliografski detalji
Izdano u:Breast Cancer Res
Glavni autori: Timms, Kirsten M, Abkevich, Victor, Hughes, Elisha, Neff, Chris, Reid, Julia, Morris, Brian, Kalva, Saritha, Potter, Jennifer, Tran, Thanh V, Chen, Jian, Iliev, Diana, Sangale, Zaina, Tikishvili, Eliso, Perry, Michael, Zharkikh, Andrey, Gutin, Alexander, Lanchbury, Jerry S
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308910/
https://ncbi.nlm.nih.gov/pubmed/25475740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0475-x
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