Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques

Insulysin (EC. 3.4.22.11) has been implicated in the clearance of β amyloid peptides through hydrolytic cleavage. To further study the action of insulysin on Aβ peptides recombinant rat insulysin was used. Cleavage of both Aβ(1–40) and Aβ(1–42)by the recombinant enzyme was shown to initially occur a...

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Publicat a:J Neurosci
Autors principals: Mukherjee, Atish, Song, Eun-suk, Kihiko-Ehmann, Muthoni, Goodman, Jack P., Pyrek, Jan St., Estus, Steven, Hersh, Louis B.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2000
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ARTICLE
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773064/
https://ncbi.nlm.nih.gov/pubmed/11102481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-23-08745.2000
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