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Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques
Insulysin (EC. 3.4.22.11) has been implicated in the clearance of β amyloid peptides through hydrolytic cleavage. To further study the action of insulysin on Aβ peptides recombinant rat insulysin was used. Cleavage of both Aβ(1–40) and Aβ(1–42)by the recombinant enzyme was shown to initially occur a...
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| Опубликовано в: : | J Neurosci |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Society for Neuroscience
2000
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6773064/ https://ncbi.nlm.nih.gov/pubmed/11102481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-23-08745.2000 |
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