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Cannabinoid Withdrawal Syndrome Is Reduced in Pre-Proenkephalin Knock-Out Mice

The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Δ9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed i...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Valverde, Olga, Maldonado, Rafael, Valjent, Emmanuel, Zimmer, Anne M., Zimmer, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773016/
https://ncbi.nlm.nih.gov/pubmed/11125007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-24-09284.2000
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