Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice

The involvement of dynorphin on Δ-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zimmer, Andreas, Valjent, Emmanuel, König, Monika, Zimmer, Anne M., Robledo, Patricia, Hahn, Heidi, Valverde, Olga, Maldonado, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763924/
https://ncbi.nlm.nih.gov/pubmed/11717384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-23-09499.2001
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